cancer slope factor

THE FUNDAMENTALS OF RISK ASSESSMENT- cancer slope factor ,Risk Goal ~~ Slope Factor Excess Lifetime Cancer Risk (ELCR) 1 E-5 or 000001 or 1 in 100,000 ~~ Ohio’s chosen risk goal A probability, an increased likelihood of a tumor occurring Hazard Index ~~ Reference Dose (RfD) Non-carcinogenic effects A representation of a threshold Below 1 these effects are probably not going to beToxicological Summary for: N-Nitrosodimethylamine (NDMA)NDMA cancer slope factor Sumi, Y, & Miyakawa, M (1983) Susceptibility of germ-free rats to the hepatotoxic effects of dimethylnitrosamine or dimethylamine plus sodium nitrite administered orally Cancer Res, 43 (6), 2942-2946 N-Nitrosodimethylamine (NDMA) - Page 5 of 5



NJDEP - Toxicity Factors for Cadmium

e = derived by multiplying the IRIS slope factor of B(a)P of 73 (mg/kg-day)-1 with the “estimated order of potential potency” for the individual Group B2 PAHs recommended in USEPA “Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons”, Office of Research and Development, EPA/600/R-93/089

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Table 1 CONSOLIDATED TABLE OF OEHHA/ARB APPROVED …

Oct 02, 2020·Table 1 CONSOLIDATED TABLE OF OEHHA/ARB APPROVED RISK ASSESSMENT HEALTH VALUESa Table last updated: October 2, 2020 1 Substance Chemical b

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Introduction to Risk Assessment - European Commission

cancer over a lifetime is estimated by multiplying the cancer slope factor (mg/kg/day) for the substance by the chronic(70-year average) daily intake (mg/kg-day) Threshold substances There is a need for exposure above a certain level before effects can be observed For each compound a …

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Slope Factors (SF) from US EPA - POPs) Toolkit

Slope Factors (SF) from US EPA Chemical Name CAS Number Oral slope factor (1/mg/kg/d) Inhalation slope factor (1/mg/kg/d) Volatile Organic Compound (VOC)?

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Slope Factor - an overview | ScienceDirect Topics

Cancer potency factor (CPF), or cancer slope factor (CSF), is a parameter that arises during the quantitative risk assessment of chemicals or agents being evaluated as carcinogens It represents a measure of cancer risk from a lifetime exposure to an agent and is typically expressed in units of proportion of a population affected per milligram

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The US EPA’s Draft Oral Slope Factor (OSF) for 2,3,7,8

Draft Candidate Cancer Slope Factors 3 Draft Candidate Cancer Slope Factors 1E+7 1E+6 1E+5 Human Occupational Mouse Rat 4 Cheng et al, 2006 Overview

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Appendix F: Derivation of Comparison Values | PHA Guidance

22 Cancer Slope Factor (CSF) and Inhalation Unit Risk (IUR) Definition/Derivation EPA evaluates the potential carcinogenicity of a substance using a two-step process—a qualitative weight-of-evidence approach and a quantitative assessment to define the relationship between dose and the likelihood of a theoretical increase in cancer cases in

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NJDEP - Toxicity Factors for Cadmium

e = derived by multiplying the IRIS slope factor of B(a)P of 73 (mg/kg-day)-1 with the “estimated order of potential potency” for the individual Group B2 PAHs recommended in USEPA “Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons”, Office of Research and Development, EPA/600/R-93/089

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Cancer Slope Factor: Definition & Calculation | Study

Answer: The cancer slope factor is a single number that is calculated by looking at toxicology data on how cancer risk rises with increased exposure to a certain compound Toxicology is the study

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Carcinogenic Toxicity-Obtaining Cancer Slope Factor

ELCR = Lifetime Average Daily Dose x Cancer Slope Factor = 009 ug/kg/d x 1 mg/10 3 ug x 15 per mg/kg/d = 135 X 10-4 The extra risk of cancer associated with lifetime exposure to arsenic in drinking water is 135 in 10,000 or approximately 001%

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Arsenic, Inorganic CASRN 7440-38-2 |IRIS|US EPA, ORD

Sep 01, 1991·Oral Slope Factor: 15 per mg/kg-day Drinking Water Unit Risk: 5 x 10 -5 per µg/L Extrapolation Method: Time- and dose-related formulation of the multistage model

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Basic Information about the Integrated Risk - US EPA

Sep 28, 2021·Oral slope factor (OSF) is an estimate of the increased cancer risk from oral exposure to a dose of 1 mg/kg-day for a lifetime The OSF can be multiplied by an estimate of lifetime exposure (in mg/kg-day) to estimate the lifetime cancer risk Inhalation

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oral slop factor | The EPA Blog

Reference Concentration (inhalation exposures) The amount of a substance that one can breathe every day for a lifetime that is not anticipated to cause harmful health effects Oral Slope Factor An estimate of the increased cancer risk from a lifetime of oral exposure to a substance Inhalation Unit Risk

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CSF 定义: 癌症斜率因子 - Cancer Slope Factor

CSF = 癌症斜率因子 正在查找 CSF 的一般定义? CSF 表示 癌症斜率因子。 我们很自豪地在最大的缩写词和首字母缩略词数据库中列出 CSF 的首字母缩略词。 下图显示了 CSF 在英语中的定义之一:癌症斜率因子。 您可以下载图像文件以打印或通过电子邮件

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Slope factor Definition | Law Insider

Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question Slope factor setting; (j) Shade factor setting; and (k) Irrigation uniformity or efficiency setting Slope factor: An upper bound, approximating a 95% confidence limit, on the increased cancer risk from a lifetime exposure to an agent Slope factor models have been used as simpler

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Slope Factor - an overview | ScienceDirect Topics

FF Farris, SD Ray, in Encyclopedia of Toxicology (Third Edition), 2014 Introduction Cancer potency factor (CPF), or cancer slope factor (CSF), is a parameter that arises during the quantitative risk assessment of chemicals or agents being evaluated as carcinogens It represents a measure of cancer risk from a lifetime exposure to an agent and is typically expressed in units of proportion

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